The flood and waterlogging disaster loss assessment is a very important component for the disaster relief work, which has important theoretical and practical significance for the research of disaster and its relief. According to the correlation analysis between the flood disaster loss and meteorological and hydrological elements, a correlation model between the area and property of flood disaster loss and historical meteorological and hydrologic factors was developed. The property loss rate and background data of permanent assets were used to evaluate the direct economic losses caused by flood disaster, which are useful for the pre-disaster preliminary assessment and post-disaster rapid assessment. In this paper, the flood of the middle reach of Huaihe River in Anhui Province in 2007 was analyzed, which provided similar assessment results of flood disaster loss with those reported data in reality. Therefore, the evaluation method is applicable and reliable.