The Middle Route of South to North Water Diversion Project (MRP) has long canals, involves many areas and hydraulic structures, transfers water by a huge amount, and has various working conditions. These all bring great difficulties to the regulation, control, and management of the project. The technical problem of the engineering lies in the fact that the scientific and mechanism problems behind it are not fully revealed and solved, including multi-dimensional equilibrium control mechanism of multiple water sources under changing conditions, multi-process coupling mechanism of water quantity and water quality, emergency scheduling model for multi-material water pollution, hydraulic response mechanism and control of open channel under multi-gate joint application. In order to establish a complete set of technical system to support its scheduling, this paper summarizes the existing research on the five key points of forecast, scheduling, simulation, control, and evaluation. And on the basis of summarizing the previous research, the key technologies awaiting urgent research are explained in detail, including forecast and scheduling in water source areas and water-receiving areas, multi-phase simulation of water pollution, water quality and water quality control, automatic control technology, evaluation technology, and platform construction. Finally, the paper discusses the scientific problems to be solved in order to realize the intelligent regulation and emergency regulation for the MRP and makes a summary of the research.