Xunsichang is located in Yibin City of south Sichuan, where belongs to the transition zone between the southern margin of Sichuan Basin and Yunnan-Guizhou Plateau with strongly developed karst and densely distributed groundwater outcrop. In this paper, the hydrogeological conditions, chemical composition of groundwater, and oxygen and hydrogen isotope data were analyzed to identify the groundwater flow path model in this area, and then the hydrogeochemical modeling method (Phreeqc reverse modeling technique) was used to verify the results. The runoff flow paths of Xiaoyudong ground river, Liangfengdong ground river, and hot spring were determined, which suggested there are no hydraulic connection between them. The simulation results were similar to those obtained from the hydrochemical and isotopic analysis. The results are of important significance for the groundwater exploitation and engineering construction in Xunsichang area.