The municipal domestic sewage was treated by a membrane bioreactor-reverse osmosis (MBR-RO) combined process. The SDI of MBR effluent was between 2.5 and 3.5, which met the demand of RO influent, and the fouling of RO membrane could be controlled after adding 10 mg/L of the antisludging agent. The product water quality of MBR-RO was good, and NH4+-N, NO2--N, TP and TOC concentrations of the effluent were respectively 0.15 mg/L, 2.82 mg/L, 0.12 mg/L and 0.51 mg/L, and the concentrations of CODMn and NO2--N were below 0.05 mg/L and 0.7 mg/L respectively in MBR-RO. According to the 73 major indexes in the national drinking water sanitary standard, the effluent could meet the drinking water quality. The result showed that MBR-RO combined process for direct potable reuse water production is feasible.