Tar geting the problems of water security and water cycle under changing environments, this paperintr oduces the basic concepts, theories, and implications of water system. From the inter disciplinary perspective, the frontier of water science deveopment will be combining natura lscience and social science so as to study the water problem under changing environments. This paper analyzes the develo pment trend of the study on nexus of hydroso cialecology. It emphasizes the importance of studies on the coupling and decoupling of water system, the sensitivity of water syst emmodeling , and the monitoring of water system. It also discusses the necessity of the coevolution and ensemble response mechanism between naturalsy stem and human system to the construction of water system coupling models. Taking Huai River basin, Poyang Lake, and Han River basin as examples, this paper illustrates the practical and guiding significance of water system theory in China from different perspectives. The further study of water system theory should streng then the internal mechanism and generalization accuracy in order to enhance the adapt ability of water system models to climate and environmental changes. The communication between water manaement decisio nmakers and researchers also should be propelled.